Beware: Clinically Significant Drug Interactions in the Treatment of HIV

Activity Preview

Drug therapy for HIV is complex, with over 20 antiretroviral drugs in six classes approved by the U.S. Food and Drug Administration. Some of these drugs, for example, are metabolized by the CYP3A isoenzymes, causing their levels to be affected by agents that induce or inhibit these enzymes. Learn about clinically significant interactions among these drugs and get the tools you need to prevent adverse outcomes associated with the interactions.

This activity is based on a live activity held March 7, 2016 in Baltimore, Maryland, as part of the APhA2016 Annual Meeting Exposition. You may stop and start the recording accordingly to participate in any speaker activities and assessments. Please record your responses and then compare your results to the live audience results if provided in the recording.


Learning Objectives

After participating in this activity, the pharmacist will be able to:

  1. Describe common pharmacologic mechanisms of drug-to-drug interactions with non-nucleoside reverse transcriptase inhibitors, protease inhibitors, and integrase strand transfer inhibitors.
  2. List drugs that have a high potential to interact with antiretroviral drugs.
  3. Establish monitoring parameters and strategies to minimize the incidence of adverse drug interactions.
  4. Evaluate the consequences of drug interactions associated with antiretroviral drugs and determine the incidence of clinical adverse effects from interactions.

Activity type: Application-based

Learning level: 2


Accreditation Information

ACPE logo

The American Pharmacists Association is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education (CPE).

To obtain 2.0 contact hours of CPE credit (0.2 CEUs) for "Beware: Clinically Significant Drug Interactions in the Treatment of HIV" complete the CPE examination and evaluation questions. Credit will be awarded upon achieving a passing grade of 70% or better. Please visit CPE monitor for your transcript.

APhA continuing pharmacy education policy provides you with two opportunities to successfully complete this continuing pharmacy education examination. Please note that you will not be permitted to submit the examination a third time. The current policy of the APhA Education Department is not to release the correct answers to any of our CPE tests. This policy is intended to maintain the integrity of the CPE activity and the test.

Individuals completing this activity by March 7, 2019 can receive credit. Individuals who participated in the live version of this activity held March 7, 2016 in Baltimore, Maryland may NOT receive credit for the home-study version of this activity.

Initial release date: March 7, 2016
Expiration date: March 7, 2019
ACPE Universal Activity Number: 0202-0000-16-010-H02-P



"Beware: Clinically Significant Drug Interactions in the Treatment of HIV” is a home-study continuing education activity for pharmacists developed by the American Pharmacists Association.



Professor of Clinical Pharmacy and Family and Community Medicine
University of California Schools of Pharmacy and Medicine
San Francisco



Betty J. Dong, PharmD declares no conflicts of interest, real or apparent, and no financial interests in any company, product, or service mentioned in this program, including grants, employment, gifts, stock holdings, and honoraria.

APhA’s editorial staff declare no conflicts of interest or financial interests in any product or service mentioned in this activity, including grants, employment, gifts, stock holdings, and honoraria. For a complete list of APhA staff disclosures, please visit the APhA website at

Conflicts of interest have been resolved through content review by Helen Sairany, PharmD, BCACP, Associate Director of Content Development at the American Pharmacists Association.



The fee for this activity is $29.00 for members and $49.00 for non-members.


System Requirements

Windows XP, Windows 2003, or Windows Vista 
Display resolution of 800x600 or higher 
Microsoft Internet Explorer 8 or later, Firefox 2.0 or later, or Google Chrome 1.0 
For Firefox and Chrome, Silverlight 1.0 or later 
Windows Media Player 9.0 or later 
Broadband Internet connection (256 Kbps or more) 
No network blocks or filters that disable streaming media 

Mac OS X 10.5 or later 
Safari 2.0.4 or later (or Firefox 2.0 or later) Silverlight 1.0 
Broadband Internet connection (256 Kbps or more)  
No network blocks or filters that disable streaming media 

You will need the most updated version of Adobe Flash Player, which can be downloaded here:


Credit Information

Activity Number Credit Amount Accreditation Period
ACPE# 0202-0000-16-010-H02-P 0.2 CEUs March 07, 2016 - March 07, 2019