Nirmatrelvir and Ritonavir (Paxlovid™):  An Oral Antiviral for the Treatment of COVID-19

Activity Preview

The U.S. Food and Drug Administration has issued several Emergency Use Authorizations for the use of COVID-19 therapeutics. Nirmatrelvir-ritonavir joins the list as the first oral antiviral to be administered in the outpatient setting for individuals with laboratory-confirmed COVID-19 who exhibit mild to moderate symptoms. We will review the indications, discuss currently available efficacy and safety data, and consider its place in therapy in light of the current dominant Omicron variant of concern. Product-specific requirements and counseling considerations will also be touched upon.

Learning Objectives

At the completion of this knowledge-based activity, pharmacists will be able to:

  • Discuss eligibility requirements for the use of nirmatrelvir in combination with ritonavir as outlined by the US Food and Drug Administration’s (FDA) Emergency Use Authorization (EUA)
  • Describe the mechanism of action of nirmatrelvir-ritonavir
  • Discuss currently available efficacy and safety data on nirmatrelvir-ritonavir in the treatment of COVID-19
  • Identify potential drug-drug interactions

Activity type: Knowledge-based
Target Audience: Pharmacists
Learning Level: 2

Accreditation Information


The American Pharmacists Association is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. The following education course is approved for 1.0 contact hour of CPE credit (0.1 CEU). The ACPE Universal Activity Number for this activity is 0202-0000-22-004-H01-P.

To obtain credit for completing Nirmatrelvir and Ritonavir (Paxlovid™):  An Oral Antiviral for the Treatment of COVID-19, participants will need to watch the archived webinar, complete the assessment with a grade of 70% or better, complete the evaluation questions, and then CLAIM credit. Participants need to have a valid username and password to claim credit. After credit has been claimed, please visit CPE monitor for your transcript.

Initial release date: January 7, 2022
Expiration date: December 31, 2023 - No credit can be earned after this date


Nirmatrelvir and Ritonavir (Paxlovid™):  An Oral Antiviral for the Treatment of COVID-19 is an activity for pharmacists developed by the American Pharmacists Association. © 2022 American Pharmacists Association


Kieu Nguyen, PharmD and APhA’s editorial staff declare no conflicts of interest or financial interests in any product or service mentioned in this activity, including grants, employment, gifts, stock holdings, and honoraria. For a complete list of APhA staff disclosures, visit the APhA website at


There is no fee associated with this activity for APhA members and non-members.

System Requirements

Computer and internet access are required to complete this activity.  Please visit our website to view the Technology System Requirements in order to have a positive learning experience.

Credit Information

Activity Number Credit Amount Accreditation Period
ACPE# 0202-0000-22-004-H01-P 0.1 CEUs January 07, 2022 - December 31, 2023